The Center for Reproductive Sciences 

Founded in 1977, the UCSF Center for Reproductive Sciences has long been a model of interdisciplinary excellence. Today, it includes 26 faculty from various departments (9) and Centers/Institutes (7) and over 100 trainees, including graduate students, basic science postdoctoral fellows, and clinical fellows. The Center’s research spans the full spectrum of reproductive biology, from gametogenesis and implantation to placentation and epigenetics, while training the next generation of leaders in reproductive science.

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Aleksandar Rajkovic

On July 5, 2025  Aleksandar Rajkovic, MD, PhD, was announced as  Director of the UCSF Center for Reproductive Sciences. Read here. 

CRS Director, Aleksandar Rajkovic, MD, PhD

To continue as a global leader in reproductive sciences, the strategic vision of the CRS will focus on:

  • Innovative Research Expansion
  • Enhanced Clinical Integration
  • Mentorship & Opportunity
  • Sustainable Growth
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lab photo

A Tradition of Research: Innovations from CRS

For almost 50 years, the UCSF Center for Reproductive Sciences has been at the forefront of discovery in reproductive science. We foster an environment where researchers use advanced approaches in genomics, epigenomics, and quantitative cell biology to generate new insights. By bringing together basic and clinical scientists, we accelerate the development of innovative diagnostics and treatments that advance reproductive health.

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poster presentation 5

Sofia Ruau (Fuh Lab) reviewing poster with former CRS  Director, Mario Conti on May 21, 2026. The study explores treatment in aggressive endometrial cancer. 

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CRS poster presentation two

Stanford instructor Dr. Dorien Feyaerts presenting on behalf of the Gaudillierre Lab. 

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poster presentation three

Postdoctoral Fellow Julia do Amaral Gomes with the Robinson Lab shares her research showing how common disinfectant chemicals found in cleaning products can harm the developing brain of embryos during early pregnancy. In laboratory studies using rat embryos and human stem cells, the researchers found that higher levels of certain QACs caused birth defects, especially affecting the brain, spinal cord, and heart, suggesting these chemicals may pose risks to early fetal development.

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poster presentation 4

Manon Miller, PhD Candidate in the Biomedical science program at UCSF presented research on ovarian cancer treatment from Dr. Fuh's Lab. 

Training the Next Generation of Leaders

More than 100 trainees—including graduate students, postdoctoral scholars, and clinical fellows conduct research across the full spectrum of reproductive biology, from gametogenesis and implantation to placentation and epigenetics.

At the 2026 CRS Retreat, trainees showcased their work through poster presentations, highlighting innovative research and fostering collaboration across the Center.

 

Research Programs and Principal Investigators

CRS research spans reproductive endocrinology, developmental and implantation biology, reproductive oncology, and fetal origins of adult disease. Although mammalian models are primarily and widely adopted for these research programs, model organisms such as yeast, Drosophila, zebra fish, and frog models of reproduction are also used to elucidate specific aspects of gamete development and function. State of the art technologies in cell and molecular biology, nucleic acid and protein biochemistry are currently in use in CRS laboratories. A large number of engineered mouse models, as well as cultured cells, including human stem cells, are also available and exchanged among the CRS members.

  1. Synthesis and mechanisms of action of steroid hormones (Sindy Mellon, Holly Ingraham)
  2. Sex-specific differences in gut-brain signaling (Holly Ingraham)
  3. Mechanism of action of gonadotropic hormones (Marco Conti)

  1. Early embryo development (Susan Fisher, Robert Blelloch, Paolo Rinaudo, Marco Conti, Daniel Wagner)
  2. Regulation of pluripotency (Robert Blelloch)
  3. Primordial germ cell specification and migration (Diana Laird)
  4. Regulation of meiotic chromosome recombination (Jennifer Fung)
  5. The gonadal "niche" and its role in pluripotency (Todd Nystul)
  6. Mechanisms of oocyte maturation, ovulation, and early embryo development (Marco Conti)
  7. Fetal origins (IVF) of adult diseases (Paolo Rinaudo)
  8. Genetics of human ovarian aging (Marcelle Cedars)

  1. Genetic programs underlying uterine receptivity (Linda Giudice)
  2. Trophoblast development and function (Susan Fisher, Emin Maltepe)
  3. Molecular signatures of endometriosis (Linda Giudice, Marina Sirota)
  4. Immunology and epigenetics of pregnancy and parturition (Adrian Erlebacher)
  5. Molecular pathways affecting immunity and pathology in reproduction (Nadia Roan)
  6. Maternal-fetal tolerance (Tippi Mackenzie)

  1. Environmental exposure and placental disease (Joshua Robinson)
  2. Toxicogenomics (Joshua Robinson)
  3. Environmental toxicant effects in meiosis (Jennifer Fung)
  4. Epigenetics and environment in germ cell development (Diana Laird)

  1. Impact of infections in pregnancy on the mother and fetus (Stephanie Gaw)
  2. Covid-19 and reproductive health (Stephanie Gaw, Joshua Robinson)

  1. Mechanisms of cell resistance to chemotherapy
  2. Stem cells and ovarian cancer (Katherine Fuh)
  3. Germ cell preservation for oncologic patients (Mitchel Rosen)

  1. Computational methods for understanding, diagnosing and treating reproductive disorders (Marina Sirota)